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14 Vascular Disease Prevention, 2004, Vol. 1, No. 1 [91] [92] Gardner AW. The effect of cigarette smoking on exercise capacity in patients with intermittent claudication. Vasc Med 1996; 1: 1816. Cameron HA, Waller PC, Ramsay LE. Drug treatment of intermittent claudication: a critical analysis of the methods and findings of published clinical trials, 1965-1985. Br J Clin Pharmacol 1988; 26: 569-76. Diehm C, Kuhn A, Strauss R, Hubsch-Muller C, Kubler W. Effects of regular physical training in a supervised class and additional intravenous prostaglandin E1 and naftidrofuryl infusion therapy in patients with intermittent claudication--a controlled study. Vasa 1989; 28 Suppl: 26-30. Scheffler P, de la Hamette D, Gross J, Mueller H, Schieffer H. Intensive vascular training in stage IIb of peripheral arterial occlusive disease. The additive effects of intravenous prostaglandin E1 or intravenous pentoxifylline during training. Circulation 1994; 90: 818-22. Ernst E, Kollar L, Resch KL. Does pentoxifylline prolong the walking distance in exercised claudicants? A placebo-controlled double-blind trial. Angiology 1992; 43: 121-5. Ehrly AM. Improvement of the flow properties of blood: a new therapeutical approach in occlusive arterial disease. Angiology 1976; 27: 188-96. Angelkort B, Maurin N, Boateng K. Influence of pentoxifylline on erythrocyte deformability in peripheral occlusive arterial disease. Curr Med Res Opin 1979; 6: 255-8. Johnson WC, Sentissi JM, Baldwin D, Hamilton J, Dion J. Treatment of claudication with pentoxifylline: are benefits related to improvement in viscosity? J Vasc Surg 1987; 6: 211-6. Angelkort B, Kiesewetter H. Influence of risk factors and coagulation phenomena on the fluidity of blood in chronic arterial occlusive disease. Scand J Clin Lab Invest 1981; 156 Suppl: 185-8. Dawson DL, Zheng Q, Worthy SA, Charles B, Bradley DV Jr. Failure of pentoxifylline or cilostazol to improve blood and plasma viscosity, fibrinogen, and erythrocyte deformability in claudication. Angiology 2002; 53: 509-20. Di Perri T, Guerrini M. Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. Angiology 1983; 34: 405. Roekaerts F, Deleers L. Trentla 400 in the treatment of intermittent claudication: results of long-term, placebo-controlled administration. Angiology 1984; 35: 396406. Strano A, Davi G, Avellone G, Novo S, Pinto A. Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs. Angiology 1984; 35: 45966. Lindgarde F, Jelnes R, Bjorkman H, et al. Conservative drug treatment in patients with moderately severe chronic occlusive peripheral arterial disease: Scandinavian Study Group. Circulation 1989; 80: 154956. Porter JM, Cutler BS, Lee BY, et al. Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Heart J 1982; 104: 66 Dettori AG, Pini M, Moratti A, et al. Acenocoumarol and pentoxifylline in intermittent claudi-cation: a controlled clinical study. The APIC Study Group. Angiology 1989; 40: 237-48. Reilly DT, Quinton DN, Barrie WW. A controlled trial of pentoxifylline Ttental 400 ; in intermittent claudication: clinical, haemostatic and rheological effects. N Z Med J 1987; 100: 445-7. Gallus AS, Gleadow F, Dupont P, Walsh J, Morley AA, Wenzel A, et al. Intermittent claudication: a double-blind crossover trial of pentoxifylline. Aust N Z J Med 1985; 15: 402 Girolami B, Bernardi E, Prins MH, Ten Cate JW, Hettiarachchi R, Prandoni P, et al. Treatment of intermittent claudication with physical training, smoking cessation, pentoxifylline, or nafronyl: a meta-analysis. Arch Intern Med 1999; 159: 337-45. Moher D, Pham B, Ausejo M, Saenz A, Hood S, Barber GG. Pharmacological management of intermittent claudication: a metaanalysis of randomised trials. Drugs 2000; 59: 1057-70. Hood SC, Moher D, Barber GG. Management of intermittent claudication with pentoxifylline: meta-analysis of randomized controlled trials. CMAJ 1996; 155: 1053-9. Ernst E. Pentoxifylline for intermittent claudication. A critical review. Angiology 1994; 45: 339-45. [113] [114] and ribavirin.
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Are summarised in tables 2 and 3. In addition, patients' completed a self assessment questionnaire during the course of the study. A handheld computer prompted the patients to answer a series of 7 questions about their abilities and quality of life at 8am, midday, 4.00pm and 8.00pm. Two additional morning questions were asked at 8am relating to the previous nights sleep. Table 4 includes details of the self assessment questions. Each question had 5 alternative responses, ranging from 1; severe disability i.e. not able to walk, `off', dyskinetic, hyperkinetic, difficulties with chores, dystonia, very depressed, and not at all satisfied ; to 5; no disability i.e. fully able to walk etc, not depressed, completely satisfied ; . Increased scores indicated an improvement. The scores for each patient were averaged over the 14 day baseline and during the 12 days of each treatment period and assessed using the PDQ 39 and 15D quality of life questionnaires. The median scores for seven out of the eight dimensions of the PDQ-39 assessment were significantly better with the infusion. The remaining dimension social support was unchanged. Median total scores of the 15D QoL instrument was increased from 0.72 to 0.78 with infusion.
Recommendation: DHS needs to assure proper response to emergency requests from ACDF. Impact: Better mental health care and improved relationship between ACDF staff and DHS staff. Barriers to Implementation: Convincing DHS that the issue is real and the perception of ACDF staff when they fail to respond. Timeline: Immediately and within 1 month. Finding No. 46. The contract psychiatrist's hours are not scheduled during the most desirable times and conflicts with the scheduled jail activities makes their time less than productive at times. In addition, during the audit CJI attempted to interview the psychiatrist when scheduled to work on two occasions and were told they could not be found. No ACDF staff had been informed that the psychiatrist was on leave or who would be covering and when. Recommendation: The contract psychiatrists hours should be scheduled in collaboration with ACDF administrators. The ACDF Assistant Director of Corrections should be notified about any change in scheduled psychiatrist hours or when they are not going to be onsite at regularly scheduled times so he knows and then can put it on roll call. Impact: Better confidence by ACDF staff about DHS contract psychiatrists. Barriers to Implementation: Possible resistance of contract psychiatrists to desired schedule. Timeline: Immediately one month.

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Forty New Zealand white rabbits male, 8-10 months, 2-2.5 kg, Kombassan Research Center, S U Konya ; were randomly divided to four equal groups. Group 1 served as a control group. Group 2: LPS Escherichia coli 0111; B4, Sigma ; was injected intravenously 400 g kg, auricular vein ; . Group 3: PEN Ttental amp, Hoechst Marion Roussel, Istanbul, Turkey ; was injected intraperitoneally 50 mg kg ; . Group 4: PEN 50 mg kg, intraperitoneally ; and LPS 400 g kg, intravenously ; were injected simultaneously. Blood samples were taken from auricular vein 6 h after the treatments. Serum samples were collected for the determining of the biochemical parameters.
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