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Lancet 349: 14291435, 1997 The EPILOG Investigators: Platelet glycoprotein IIb IIIa receptor blockade and lowdose heparin during percutaneous coronary revascularization. N Engl J Med 336: 1689 1696, Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms PRISM-PLUS ; Study Investigators: Inhibition of the platelet glycoprotein IIb IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. N Engl J Med 338: 14881497, 1998 The PURSUIT Trial Investigators: Platelet Glycoprotein IIb IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy: inhibition of platelet glycoprotein IIb IIIa with eptifibatide in patients with acute coronary syndromes. N Engl J Med 339: 436443, 1998 The EPISTENT Investigators: Evaluation of Platelet IIb IIIa Inhibitor for Stenting: randomised placebo-controlled and balloonangioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb IIIa blockade. Lancet 352: 8792, 1998 The Bypass Angioplasty Revascularization Investigation BARI ; Investigators: Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med 335: 217 225 and hydrodiuril.
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Treatment Group: Placebo Adverse Event: MEDRA code Overdose NOS [ADECS code Abnormal Laboratory Value Unintentional Overdose of Study Medication ; ] Case reference number 2000028248-1 is a clinical trial report from blinded study 29060 676 for Social Anxiety Disorder. This report refers to a 10-year-old white male patient identification number 676.209.24958 ; . The patient had no previous or current significant medical history reported. No previous or concomitant medications were reported during the study. Psychiatric history measured by the ADIS C P semi-structured interview ; included an overall diagnostic label of Social Anxiety Disorder. The patient received the first dose of study medication at level 1 10 mg day ; on 01 August 2000. The dose was gradually increased to level 4 40 mg day ; on 11 September 2000 Day 42 ; and remained at that dose until the start of the taper phase on 21 November 2000 Day 113 ; . The patient received the last dose of study medication on 11 December 2000 Day 133 ; . From 11 September 2000, some 41 days after the first dose, the patient accidentally overdosed on study medication. The patient had taken four capsules daily instead of the recommended two capsules. The patient was asymptomatic. The patient did not receive any corrective therapy for the event. Treatment with study medication was not stopped due to this event. The event resolved on 21 September 2000. The investigator considered this to be a serious event because it was an overdose. The investigator reported the overdose to be mild in intensity and related to treatment with study medication, because drugs.
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Terpenes Triterpenes Sterols Beta-Sitosterol, etc. Plant sterols or phytosterols are terpenic compounds found in the unsaponifiable part of crude vegetable oils. Stanols, on the other hand, belong to the group of 4-desmethylsterols and are hydrogenation products of the respective plant sterols. There are over 40 phytosterols, but beta-sitosterol is the most abundant one, comprising about 50 % of dietary phytosterols. Chemically, beta-sitosterol is a very close relative of cholesterol. It differs from cholesterol by the presence of an ethyl group at the 24th carbon position of the side chain. Beta-Sitosterol is extremely insoluble in aqueous media and poorly soluble in lipid media. It is found in nature in ester and glycoside forms, both of which forms are more soluble than betaSitosterol itself. The next most abundant phytosterols are campesterol about 33 % ; and stigmasterol about 2 to 5 % ; Other phytosterols found in the diet include brassicasterol, delta-7-stigmasterol and delta-7-avenasterol. Fruits, vegetables, nuts and seeds, etc. AOCS Ch 6-91 Determination of the composition of the sterol fraction of animal and vegetable oils and fats by TLC and capillary GLC Official Methods and Recommended Practices of the AOCS 5th Edition, 1998 ; . This method specifies a thin-layer chromatography-capillary gas chromatographic method for the determination of the composition of the sterol fraction of animal and vegetable oils and fats. The method requires the saponification of a test portion of sample, extraction of the unsaponifiable matter and separation of sterols in the unsaponifiable matter by thin-layer chromatography, followed by the analysis of the separated sterols by gas chromatography using capillary columns. The results can be used to check the purity of a fat. Purity check of olive oil Phytosterols are structured like cholesterol and, when present in sufficient amounts, they block the absorption of cholesterol. As a result, it is claimed that less cholesterol passes into the bloodstream and more cholesterol passes out of the body. Thus, they may reduce the risk of coronary heart disease.
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