UNSTRESSED ADJ: H-NORMAL ; , s-s: a-s npsych, b-r h-n hd cran strl, nl, 18359 ; . UNSUCCESSFUL ADJ: H-RESP ; , response: 8166 ; . UNSUCCESSFULLY D: H-RESP ; , response: 18360 ; . UNSUPPORTED ADJ: H-DESCR ; , md: 18362 ; . UNSUPPORTED D: H-DESCR ; , md: 18361 ; . UNSURE ADJ: H-MODAL ; , md: md modal, 18363 ; . UNTESTABLE ADJ: H-TXRES ; , s-s: pr eval, 1010595 ; . UNTIL CS1: H-TMPREP ; , tm: tm tm-prp, 1081 ; . UNTIL CS2: H-TMPREP ; , tm: tm tm-prp, 5708 ; . UNTIL CS4: H-TMPREP ; , tm: tm tm-prp, 1082 ; . UNTIL P: H-TMPREP ; , tm: tm tm-prp, 1628 ; . UNTIL AFTER CS1: H-TMPREP ; , tm: tm tm-prp, 33766 ; . UNTIL AFTER CS2: H-TMPREP ; , tm: tm tm-prp, 33767 ; . UNTIL AFTER CS4: H-TMPREP ; , tm: tm tm-prp, 33837 ; . UNTIL AFTER P: H-TMPREP ; , tm: tm tm-prp, 33763 ; . UNTOWARD ADJ: H-INDIC ; , s-s: 18364 ; . UNTREATED ADJ: H-TTCOMP ; , trt-rec: 18365 ; . UNUNITED ADJ: H-INDIC ; , s-s: 18366 ; . UNUSUAL ADJ: H-DESCR ; , md: md des, 18367 ; . UNUSUALLY D. UNVERRICHT-LUNDBORG N: SI: H-DIAG ; , dx: 18369 ; . UNWANTED ADJ: H-DESCR ; . UNWELL ADJ: H-INDIC ; , s-s: 18370 ; . UNWILLING ADJ: H-NEG ; , md: md ng, 18371 ; . UNWILLINGNESS N: SI: H-NEG ; , md: md ng, 18372 ; . UNWITNESSED ADJ: H-DESCR ; , pr: pr mgt, 201444 ; . UP DP, p-o: 1102 ; . UP P, p-o: 4385 ; . UP D: H-CHANGE-MORE ; , md: md chg-more, 6096 ; . UP AND AROUND ADJ: H-PTFUNC ; , phy-fun: act adl, 1005938 ; . UP FROM CS4, p-o: 1010403 ; . UP FROM P, p-o: 1010404 ; . UP STROKE N: SI: H-PTFUNC ; , phy-fun: a-s cv hrt myc, b-r tk thx intthor mediast, 1008296 ; . UP STROKES N: PL: H-PTFUNC ; , phy-fun: a-s cv hrt myc, b-r tk thx intthor mediast, 1008297 ; . UP TO D, md: md amt, 4372 ; . UP TO H-AMT ; , md: md amt, 6157 ; . UP-SLOPING ADJ: H-DESCR ; , p-o: 8169 ; . UP-TO-DATE ADJ: H-TMLOC ; , tm: tm tm-loc, 201621 ; . July 15, 2005.
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The Center's long-term effort to mechanize the sample preparation of tablets and capsules was continued. A more advanced model of a system that automatically prepares, collects, and stores slurries of tablets or capsules was completed. The prototype of an automatic sampler, which sequentially samples the tablet or capsule solutions and passes them to a continuous-flow analyzer, was constructed. In 1979 the Center installed a new Hewlett-Packard 1000 Computing System with 256, 000 bytes of main memory. The system is operational, and most of the main programs are already installed in the new system. Plans for further expansion call for increasing the amount of main memory to 512, 000 bytes and installing seven more remote terminals by September 30, 1980. Data-base management systems are also being proposed. Programs to acquire and smooth data from continuous-flow analyzers were written for use by a microprocessor system. The interface between the microprocessor and an AutoAnalyzer Colorimeter II was completed.
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Figure 1 shows a typical chromatographic separation of the five cephalosporins at their clinically significant concentrations ; , obtained by subjecting 0.1 mL of the human serum samples to the analytical procedure. In this assay, both cefixime and cephalexin served as internal standards. Cefixime was used as the internal standard for the determination of cefaclor, cefadroxil, cephalexin, and cephradine, while cephalexin was used as the internal standard for the determination of cefixime. For the linearity studies we assayed seven different concentrations 1, 2, 5, and 100 mg L ; of cefaclor, cefadroxil, cephalexin, and cephradine, and of cefixime 0.1, 0.2, 0.5, and 10 mg L ; .The detector response peak height ratio ; was linear over the concentration ranges studied. Standard curves were obtained by plotting the added drug concentration mgfL ; vs the peak-height ratio drug: internal standard ; . For linear least-squares regression analysis of the data we used a laboratory automation system Model 3357; Hewlett-Packard, Paramus, NJ ; and SAS# Institute Inc., Cary, NC the results are present SAS ed in Table 1. Precision and accuracy. Analytical recovery experiments were performed by adding the individual cephalosporins to serum or methanol samples. Serum samples were extracted according to the procedure previously described. The recovery of each cephalosporin from the drug-supplemented human serum samples, calculated with respect to methanol samples similarly prepared, was 81.4% over the concentration ranges studied for all compounds except cefaclor Table 2 ; . The lower mean net recovery for cefaclor may result from its limited solubility in mobile phase. This could present a problem at concentrations 50 mg L, but such concentrations of cefaclor are not normally observed clinically 10 ; . Within-day CV, over the concentration range studied, was and coumadin.
Disorder e.g. McGrath, 1991 ; . In an indirect test of this hypothesis, Kuperberg et al. 2000 ; measured reaction times of thought-disordered patients and control subjects to target words presented in the context of pragmatically, semantically or syntactically erroneous sentences. They found heterogeneity between individual thought-disordered patients in their sensitivity to different types of linguistic violations. In addition, they observed an inverse relationship between severity of thought disorder and sensitivity to linguistic violations within individual patients, over time, indicating that sensitivity to linguistic errors was related to the state, rather than the trait, of thought disorder. Some other investigators have found that errors in speech monitoring are a feature of schizophrenia, but are not related to specific symptom types. For example, Leudar et al. 1994 ; used the position of interruptions of the speechflow to repair errors as an indicator of whether the detection of the errors was performed through monitoring of internal phonetic plans or through external acoustic feedback. They found that internal error detection was twice as frequent in healthy controls as in schizophrenic patients, but did not find.
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We are left with the problem of the ability to appropriate knowledge. The propensity to patent is high in the pharmaceutical industry because scientific knowledge can be summed up in a chemical formula expressed as a sequence of letters. The patent therefore constitutes a priority means of appropriation "because the cost of duplicating an innovation is less than the initial cost of invention" ARUNDEL and KABLA, &1998 ; . Table VI - The propensity to patent by sector Weighted average by sales ; Number of companies Textiles - clothing Oil refining Chemicals Pharmacology Automobile 9 17 88 Product innovations 8, 1 % 22, 6 % 57, 3 % 79, 2 % 30, 0 % Process innovations 8, 0 % 29, 0 % 39, 0 % 45, 6 % 17, 0.
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Fig. 4. CSF concentration versus time profiles of GlySar, cephalexin, and cefaclor after intracerebroventricular administration. [3H]GlySar A ; , cefalexin B ; , and cefaclor C ; were administered into the lateral ventricle of rats. The initial concentration of [3H]GlySar was 20 nM in the CSF, whereas that of cefalexin and cefaclor was 13 M. The concentration of ligand remaining in the cisternal CSF was determined at the designated times. [14C]Mannitol open triangles ; was coadministered as a reference for CSF turnover and passive diffusion into the brain parenchyma. The values are expressed as the percentage of the dose remaining per milliliter of CSF. Each point represents the mean S.E. of triplicate determinations using three rats. The solid lines represent the fitted elimination curve and cipro.
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